2011 Fiscal Year Final Research Report
Analysis of osteoblastic differentiation enhanced by inhibition of SUMOylation.
| Project/Area Number |
22791781
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
YUKITA Akira 松本歯科大学, 歯学部, 助教 (80401214)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 再生医療 / 骨芽細胞 / 分化制御 / SUMO化修飾 |
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| Research Abstract |
Osteoblastic differentiation is enhanced by Bone Morphogenetic Proteins(BMPs). Recently, we reported that SUMOylation of Smad4 which is a transcriptional factor involved in the BMP signaling inhibits osteoblastic differentiation induced by BMPs. In this study, I performed a global analysis of gene expression by cDNA microarray analysis, and identified several genes encoding the transcriptional factors those are expected to be important for osteoblastic differentiation.
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