2011 Fiscal Year Final Research Report
The analysis of binding of CTGF/CCN2 to RANK and its effects on RANK/RANKL signaling
| Project/Area Number |
22791788
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
AOYAMA Eriko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
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| Research Collaborator |
TAKIGAWA Masaharu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
KUBOTA Satoshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
NISHIDA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
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| Project Period (FY) |
2010 – 2011
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| Keywords | CTGF/CCN2 / RANK / OPG / RANKL / RAW264. 7 / SPR / MAPK |
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| Research Abstract |
CCN2/CTGF which is a member of CCN2 family proteins binds to various cytokines and modulates the effects. We screened the binding proteins to CCN2/CTGF and found receptor activator of NF-kappaB(RANK). CCN2/CTGF also could bind to OPG which was a decoy receptor and inhibited the effect of RANK. In the RAW264. 7, preosteoclast, CCN2/CTGF augmented the stimulation of RANKL(RANK ligand) and attenuated the inhibitory effect of OPG on RANK/RANKL signaling. These data showed that CCN2/CTGF enhanced differentiation of osteoclast via two different pathways.
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