2011 Fiscal Year Final Research Report
Mechanisms of cancer-induced pain in orofacial cancer model of rats
| Project/Area Number |
22791794
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
ONO Kentaro 九州歯科大学, 歯学部, 准教授 (40316154)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 顔面癌 / 三叉神経節 / ミクログリア / アストロサイト |
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| Research Abstract |
Since orofacial cancer-induced pain causes difficulties in eating, the symptoms of patients with orofacial cancer may be more severe than those of patients with cancer in other regions. In the present study, we investigated mechanism of cancer-induced pain in a rat facial cancer model. Consequently, we have demonstrated that cancer-induced pain is caused by central glial hyper-activation, independently on inflammation and nerve injury. The result suggests that anti-glial activation drugs may be available to inhibit cancer-induced pain in clinical side.
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