Neural mechanisms underlying the improvement of blood flow in the jaw muscles evoked by vagal afferent stimulation

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791796
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: ISHII Hisayoshi 北海道医療大学, 歯学部, 講師 (00275489)
• Project Period (FY): 2010 – 2011
• Keywords: 副交感神経 / 血管拡張反応 / 迷走神経 / 孤束核 / GABA受容体 / 咀嚼筋 / 中枢神経

Research Abstract

The present study examined the neural mechanisms underlying the improvement of blood flow in the masseter muscle evoked by vagal afferent stimulation. Our results indicate that cervical vagus nerve stimulation elicits the increase of blood flow in the rat masseter muscle mediated by vagal-parasympathetic reflex vasodilatation, and suggest that nucleus of the solitary tract play an important role in the blood flow increase in the jaw muscles.

Research Products

• [Journal Article] GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle (2012)
  • Author(s): Ishii H and Izumi H.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 302 Pages: R776-R784
  • DOI: DOI:10.1152/ajpregu.00569.2011
  • Peer Reviewed
• [Journal Article] Anterior hypothalamic inhibition of reflex parasympathetic vasodilatation in the lower lip and palate of anaesthetized cats (2011)
  • Author(s): Izumi H, Ishii H and Mizuta K.
  • Journal Title: Dent J Health Sci Univ Hokkaido Volume: 30 Pages: 43-52
  • URL: http://www.hoku-iryo-u.ac.jp/?dental-society/
  • Peer Reviewed
• [Journal Article] レーザースペックル血流計による血流動態のイメージング解析 (2011)
  • Author(s): 新岡丈治、石井久淑、和泉博之
  • Journal Title: 北医療大歯誌(総説) Volume: 30 Pages: 9-21
  • URL: http://www.hoku-iryo-u.ac.jp/?dental-society/
  • Peer Reviewed
• [Journal Article] Parasympathetic reflex vasodilatation in the masseter muscle compensates for carotid hypoperfusion during the vagus-mediated depressor response (2011)
  • Author(s): Ishii H, Niioka T and Izumi H.
  • Journal Title: Brain Res Volume: 1370 Pages: 145-153
  • DOI: DOI:10.1016/j.brainres.2010.11.046
  • Peer Reviewed
• [Journal Article] 咀嚼筋の自律神経性血流調節に関する末梢性及び中枢性神経機構 (2010)
  • Author(s): 石井久淑、和泉博之
  • Journal Title: 自律神経(総説) Volume: 47 Pages: 340-349
  • URL: http://www.jsnr-net.jp/
• [Journal Article] Vasodilator responses mediated by autonomic nervous system in the jaw muscles (2010)
  • Author(s): Ishii H and Izumi H.
  • Journal Title: Dent J Health Sci Univ Hokkaido(Review) Volume: 29 Pages: 1-23
  • URL: http://www.hoku-iryo-u.ac.jp/?dental-society/29-1.pdf
  • Peer Reviewed
• [Journal Article] Vagal visceral inputs to the nucleus of the solitary tract : involvement in a parasympathetic reflex vasodilator pathway in the rat masseter muscle (2010)
  • Author(s): Ishii H, Niioka T and Izumi H.
  • Journal Title: Brain Res Volume: 1312 Pages: 41-53
  • DOI: DOI:10.1016/j.brainres.2009.11.073
  • Peer Reviewed
• [Presentation] GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle (2012)
  • Author(s): Ishii H and Izumi H.
  • Organizer: The Proceedings of the 89th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Nagano, Matsumoto Bunka Kaikan
  • Year and Date: 2012-03-29
• [Presentation] 三叉神経領域の侵害入力による咀嚼筋の副交感神経性血管拡張反応の抑制作用 (2011)
  • Author(s): 石井久淑、和泉博之
  • Organizer: 第53回歯科基礎医学会学術大会
  • Place of Presentation: 岐阜、長良川国際会議場
  • Year and Date: 2011-10-01
• [Presentation] Imaging analysis of parasympathetic vasodilatation in vasa nervorum ofrat facial nerve with laser speckle imaging flowmeter (2011)
  • Author(s): Niioka T, Ishii H and Izumi H.
  • Organizer: The Proceedings of the 88th Annual Meeting of the Physiological Society of Japan and the 116th Annual Meeting of the Japanese Association of Anatomists
  • Place of Presentation: Kanagawa, PACIFICO YOKOHAMA
  • Year and Date: 2011-03-28
• [Presentation] Parasympathetic masseter vasodilatation compensates for carotid hypoperfusion (2011)
  • Author(s): Izumi H, Ishii H and Niioka T.
  • Organizer: 89th General session & Exhibition of the International Association for Dental Research
  • Place of Presentation: San Diego, USA, San Diego Convention Center
  • Year and Date: 2011-03-17
• [Presentation] 咀嚼筋の副交感神経性血管拡張反応は顔面・頭部領域の血流維持に関与する (2010)
  • Author(s): 石井久淑、新岡丈治、和泉博之
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: 東京、タワーホール船堀
  • Year and Date: 2010-09-21
• [Presentation] Involvement of visceral inputs in vasodilatation in the masseter muscle (2010)
  • Author(s): Izumi H, Ishii H and Niioka T.
  • Organizer: 88th General session & Exhibition of the International Association for Dental Research
  • Place of Presentation: Spain, Centre de Convencions Internacional Barcelona
  • Year and Date: 2010-07-16
• [Presentation] Involvement of vagal visceral inputs to the nucleus of the solitary tractin parasympathetic reflex vasodilatation in the rat masseter muscle (2010)
  • Author(s): Ishii H, Niioka T and Izumi H.
  • Organizer: The Proceedings of the 87th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Iwate, Morioka Civic Cultural Hall
  • Year and Date: 2010-05-20
• [Remarks]
  • URL: http://www.hoku-iryo-u.ac.jp/?physiol/