2011 Fiscal Year Final Research Report
The role of Wnt signaling in the articular surface cells functions.
| Project/Area Number |
22791799
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 関節軟骨 / 再生医学 / 細胞・組織 / 遺伝子 / 軟骨 / Wnt/β-catenin |
|---|
| Research Abstract |
The surface of articular cartilage is covered with unique cells called superficial cells. To keep maintaining articular function under the loaded circumstances, it is important to activate superficial cells. The aim of this study is to investigate the characteristics of superficial cells, and the pathological and recovery mechanisms in articular cartilage injuries. This study found that the superficial cells had undifferentiated chondro progenitor cell-like properties, that was controlled by Wnt/β-catenin signaling using gain-and loss of function of β-catenin model mice.
|
Research Products
(9 results)
-
-
-
[Journal Article] Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1βvia late phase activation of nuclear factorκB and expression of phagocyte-type NADPH oxidase2011
Author(s)
Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.
-
Journal Title
J Biol Chem.
Volume: 286(17)
Pages: 14744-52
Peer Reviewed
-
-
-
-
-
-
