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2011 Fiscal Year Final Research Report

The role of Wnt signaling in the articular surface cells functions.

Research Project

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Project/Area Number 22791799
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionShowa University

Principal Investigator

YASUHARA Rika  昭和大学, 歯学部, 助教 (20453649)

Project Period (FY) 2010 – 2011
Keywords関節軟骨 / 再生医学 / 細胞・組織 / 遺伝子 / 軟骨 / Wnt/β-catenin
Research Abstract

The surface of articular cartilage is covered with unique cells called superficial cells. To keep maintaining articular function under the loaded circumstances, it is important to activate superficial cells. The aim of this study is to investigate the characteristics of superficial cells, and the pathological and recovery mechanisms in articular cartilage injuries. This study found that the superficial cells had undifferentiated chondro progenitor cell-like properties, that was controlled by Wnt/β-catenin signaling using gain-and loss of function of β-catenin model mice.

  • Research Products

    (9 results)

All 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Roles ofβ-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells2011

    • Author(s)
      Yasuhara R, Ohta Y, Yuasa T, Kondo N, Hoang T, Addya S, Fortina P, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.
    • Journal Title

      Lab Invest.

      Volume: 91(12) Pages: 1739-52

    • Peer Reviewed
  • [Journal Article] Roles of Gingipains in Periodontal Bone loss2011

    • Author(s)
      Yasuhara R., Miyamoto M.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 53(3) Pages: 197-205

    • Peer Reviewed
  • [Journal Article] Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1βvia late phase activation of nuclear factorκB and expression of phagocyte-type NADPH oxidase2011

    • Author(s)
      Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R.
    • Journal Title

      J Biol Chem.

      Volume: 286(17) Pages: 14744-52

    • Peer Reviewed
  • [Journal Article] Intervertebral disc development is regulated by Wnt/β-catenin signaling2011

    • Author(s)
      Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, Yasuhara R, Pacifici M, Zhang Y, Iwamoto M, Enomoto-Iwamoto M.
    • Journal Title

      Spine

      Volume: 36(8) Pages: E513-8

    • Peer Reviewed
  • [Journal Article] Wnt/β-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover2010

    • Author(s)
      Yasuhara R, Yuasa T, Williams JA, Byers SW, Shah S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.
    • Journal Title

      J Biol Chem.

      Volume: 285(1) Pages: 317-27

    • Peer Reviewed
  • [Presentation] The cross talks between Wnt/β-catenin and Rac-1 Signaling in Regulation of Maintenance and Function of Superficial Cell Layer in Articular Cartilage2011

    • Author(s)
      Yasuhara R., 他6名
    • Organizer
      The International Osteoporosis Federation 2nd Asia-Pacific Osteoporosis and Bone Meeting
    • Place of Presentation
      Gold coast, Australia
    • Year and Date
      20110904-08
  • [Presentation] 関節表層細胞の維持と機能調節におけるWnt/β-cateninとRac1シグナルのクロストーク2011

    • Author(s)
      安原理佳, 他4名
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      20110728-30
  • [Presentation] Essential Roles of Wnt/β-catenin Signaling in Regulation of Structure and Function of Articular Surface Layer2010

    • Author(s)
      Yasuhara R., 他7名
    • Organizer
      50th annual meeting of The American Society For Cell Biology
    • Place of Presentation
      Philadelphia, PA, USA
    • Year and Date
      20101200
  • [Presentation] (受賞講演)リシン特異的ジンジパインは破骨細胞の分化誘導に対して、OPGを分解する事で、LPSや活性型ビタミンD_3の作用を増強する.歯科基礎医学会賞受賞講演2010

    • Author(s)
      安原理佳
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      20100900

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Published: 2013-07-31  

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