2011 Fiscal Year Final Research Report
Analysis of the regulation of bone metabolism by the pool of osteoclast precursors
| Project/Area Number |
22791804
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 破骨細胞前駆細胞(QOP) / RANK / c-Fms / c-Fos |
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| Research Abstract |
We examined the characteristics of osteoclast precursors in vivo, and found that the precursor are specific myeloid cells, not common monocytes or macrophages. We named these precursors "cell cycle-arrested quiescent osteoclast precursors(QOP). QOP differentiate into osteoclasts without cell cycle progression. In the present study, I revealed that (1) QOP circulate in the blood and settle in the bone in response to bone resorption stimuli, (2) the expression level of RANK is up-regulated by M-CSF(CSF1) in the QOP along the bone surface, and the expression of c-Fos in the QOP is also necessary for the up-regulation of RANK.
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[Journal Article] Daily administration of eldecalcitol(ED-71), an active vitamin D analog, increase bone mineral density by suppressing RANKL expression in mouse trabecular bone2012
Author(s)
Harada S(1). Mizoguchi T(equal contribution)(2), (他9名), Kobayashi Y, Nakamichi Y, Takeda S, Takahashi F, Saito H, Yasuda H, Udagawa N, Suda T, Takahashi N.
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Journal Title
J Bone Miner Res
Volume: 27
Pages: 461-473
Peer Reviewed
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