2011 Fiscal Year Final Research Report
Roles of an immunoregulatory molecule B7-H1 in pathogenesis of periodontitis
| Project/Area Number |
22791809
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
KAMIMURA Yosuke 東京医科歯科大学, 大学院・医歯学総合研究科, 非常勤講師 (40549929)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 免疫 / 感染 / 炎症 |
|---|
| Research Abstract |
Proliferative responses of keratinocytes in the skin and the gingiva that overexpressed an immunoregulatory molecule B7-H1 were accelerated. Early inflammatory skin responses were suppressed by B7-H1 on keratinocytes in a PD-1-dependent manner, but the inflammatory responses in the gingiva were impaired. A murine model of periodontitis was induced by a TDC60 strain of Prophyromonas gingivalis. Serum titers of TDC60-specific IgG were markedly elevated in the mice that exhibited severe alveolar bone loss.
|
