2011 Fiscal Year Final Research Report
The role of acid sensing nociceptors in the development of cancer-induced bone pain
| Project/Area Number |
22791811
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka Medical College (2011)
Osaka University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨転移 / 癌性疼痛 / 酸感受性受容体 |
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| Research Abstract |
The pH-sensitive fluorescence dye indicated that acidic microenvironment was created in bone metastases of rats. It was suggested that acidic microenvironment activate acid sensing nociceptors in the sensory neurons, which in turn leads to up-regulation of CGRP expression. These events may be involved in the pathophysiology of bone pain.
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