2011 Fiscal Year Final Research Report
Difference of cell cycle between nifedipine responders and non-responders
| Project/Area Number |
22791815
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
TAKEUCHI Reiri 日本大学, 松戸歯学部, 助手(専任扱) (60419778)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 薬物性歯肉増殖症 / ニフェジピン / 歯肉線維芽細胞 / 細胞周期 / アポトーシス / リポ多糖 |
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| Research Abstract |
In this study, to elucidate the cause of nifedipine-induced gingival overgrowth, it has been evaluated whether there is differences in the cell cycle phase distribution and the apoptosis in the presence of lipopolysaccharide between gingival fibroblasts derived from patients with/without gingival overgrowth during nifedipine-treatment. Nifedipine reactive cells underwent the enhanced cell cycle progression, the diminished apoptosis, and the decreased expression of apoptosis regulatory proteins(Bax, Cytochrome c, Caspase-3 and-9) in comparison with nifedipine non-reactive cells.
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