2011 Fiscal Year Final Research Report
The correlation between salivary EGF levels and recurrent oral manifestations in patients with Sjogren's syndrome
| Project/Area Number |
22791820
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
AZUMA Naoto 兵庫医科大学, 医学部, 助教 (10461039)
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| Research Collaborator |
KATADA Yoshinori 国立病院機構大阪南医療センター, アレルギー科, 医長
KANDA Chieri 兵庫医科大学, 医学部, 大学院生
KITANO Sachie 兵庫医科大学, 医学部, 実験助手
NISHIOKA Aki 兵庫医科大学, 医学部, 医員 (90412030)
SEKIGUCHI Masahiro 兵庫医科大学, 医学部, 助教 (50528958)
KITANO Masayasu 兵庫医科大学, 医学部, 助教 (00412031)
MATSUI Kiyoshi 兵庫医科大学, 医学部, 非常勤医師 (00291815)
SANO Hajime 兵庫医科大学, 医学部, 主任教授 (00196304)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫・感染・炎症 / シェーグレン症候群 / 唾液中EGF |
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| Research Abstract |
Salivary epidermal growth factor(EGF) plays a role in healing of damaged oral mucosa. However, the kinetics of salivary EGF in Sjogren's Syndrome(SS) is not well-documented. The objective of this study was to assess changes in salivary EGF and the correlation between salivary EGF and the severity of oral manifestations in patients with SS. Consequently, in SS, not only saliva volume but salivary EGF output remain reduced throughout. Lower salivary EGF level is impairments of the saliva quality associate with recurrent oral manifestations.
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