2011 Fiscal Year Final Research Report
Basic research of the development of new pulp capping agent
| Project/Area Number |
22791841
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 直接覆髄 / フォスフォフォリン / コラーゲン / 修復象牙質 / 水酸化カルシウム製剤 / 象牙細管 / 石灰化 / 生体親和性 |
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| Research Abstract |
Phosphophoryn is an important protein in dentin mineralization. It was extracted from porcine teeth, and was combined with type 1 collagen as a trial material. This trial material was placed onto the exposed pulp in maxillary first molar of 8 week-old Wistar rats. Rats were sacrificed 2-4 weeks after operation, and teeth were cut for mesial-distal plane by using an automatic grinder. Sections were analyzed by scanning electron microscopy. In trial material group, reparative dentin had dentinal tubules, and enough to seal exposed pulp area compared with calcium hydroxide, a common material. Therefore, this material was suggested to have a potential as an alternative material of calcium hydroxide.
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