2011 Fiscal Year Final Research Report
Development of cell-based skeletal muscle graft materials for the tongue and masticatory muscle tissue engineering
| Project/Area Number |
22791879
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 歯科補綴学一般 / 幹細胞 / 組織工学 / 骨格筋 |
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| Research Abstract |
The skeletal myogenesis of bone marrow-derived mesenchymal stem cells(BMSCs) offers great therapeutic promise. This research project proposes a simple method for accelerating the skeletal myogenesis of BMSCs with an aligned structure by applying cyclic strain. In addition, increasing the amplitude of the stretching device after cell alignment allowed us to obtain aligned cells as a cell sheet. This simple method based on cyclic strain may facilitate the development of a cell-based implant material that displays an in vivo-like pattern of organization.
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