2011 Fiscal Year Final Research Report
Development of an osteogenesis-inducible material using possible inflammation control of SVVYGLR functional peptide
| Project/Area Number |
22791882
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 歯科補綴学一般 / SVVYGLR / 骨芽細胞 / 破骨細 / 炎症 |
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| Research Abstract |
Effects of the functional peptide SVVYGLR on osteoblasts and osteoclasts during bone regeneration was investigated aiming at development of an osteogenesis-inducible peptide material by its possible inflammation control. The synthetic SVVYGLR peptide(1-10μg/ site) did not show apparent anti-inflammatory effects on the rat calvaria bone regeneration and on the implant osseointegration in the rat femurs. On the other hand, significant inhibitory effects of the peptide on osteoclast activities during bone regeneration were revealed
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