2011 Fiscal Year Final Research Report

Development of New Implant Augmentation Drug Delivery System Using a rh-BMP-2-Gelatin Hydrogel Complex

Research Project

Project/Area Number	22791886
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Prosthetic dentistry
Research Institution	Hiroshima University
Principal Investigator	HAYASHI Kazuhiko 広島大学, 大学院・医歯薬学総合研究科, 助教 (90444687)
Project Period (FY)	2010 – 2011
Keywords	歯科補綴学一般
Research Abstract	Optimum dose of rh-BMP-2in gelatin complex was clarified using the bone deficit model of the rabbit parietal bone. The complex was transplanted to the bone deficit model of a hybrid dog. After the observation period, the organization block was extracted, and the specimen was produced and was observed histologically. The bone tissue reproduced inside the bone deficit was observed. When rh-BMP-2quantity became large, the rate of bone area became large.