Enhancement of biocompatibility of beta-tricalcium phosphate bone substitute by anti-oxidant amino acid derivative

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791903
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: YAMADA Masahiro 東京歯科大学, 歯学部, 助教 (90549982)
• Project Period (FY): 2010 – 2011
• Keywords: 顎顔面補綴学

Research Abstract

Osteoblastic viability and functional expression on beta-tricalcium phosphate(β-TCP) were improved by application of anti-oxidant amino acid derivative, N-acetyl cysteine(NAC), on the material. It was indicated that NAC enhanced bone regeneration onβ-TCP material.

Research Products

• [Journal Article] The inhibition of infection by wound pathogens on scaffold in tissue-forming process using N-acetyl cysteine (2011)
  • Author(s): Yamada M, Ishihara K, Ogawa T, Sakurai K
  • Journal Title: Biomaterials Volume: 32巻 Pages: 8474-85
  • DOI: doi:10.1016/j.biomaterials.2011.07.074
  • Peer Reviewed
• [Journal Article] Improvement in the osteoblastic cellular response to a commercial collagen membrane and demineralized freeze-dried bone by an amino acid derivative : an in vitro study (2011)
  • Author(s): Yamada M, Kojima N, Att W, Minamikawa H, Sakurai K, Ogawa T
  • Journal Title: Clin Oral Implants Res. Volume: 22巻 Pages: 165-72
  • DOI: doi:10.1111/j.1600-0501.2010.01975.x.
  • Peer Reviewed
• [Journal Article] Effect of N-acetylcysteine on rat dental pulp cells cultured on mineral trioxide aggregate (2011)
  • Author(s): Minamikawa H, Yamada M, Deyama Y, Suzuki K, Kaga M, Yawaka Y, Ogawa T
  • Journal Title: J Endod. Volume: 37巻 Pages: 637-41
  • Peer Reviewed
• [Journal Article] Alleviation of commercial collagen sponge-and membrane-induced apoptosis and dysfunction in cultured osteoblasts by an amino acid derivative (2010)
  • Author(s): Yamada M, Kubo K, Ueno T, Iwasa F, Att W, Hori N, Ogawa T
  • Journal Title: Int J Oral Maxillofac Implants. Volume: 25巻 Pages: 939-46
  • Peer Reviewed
• [Journal Article] Amino acid derivative-mediated detoxification and functionalization of dual cure dental restorative material for dental pulp cell mineralization (2010)
  • Author(s): Minamikawa H, Yamada M, Iwasa F, Ueno T, Deyama Y, Suzuki K, Yawaka Y, Ogawa T
  • Journal Title: Biomaterials Volume: 31巻 Pages: 7213-25
  • Peer Reviewed
• [Journal Article] N-acetyl Cysteine Improves Affinity of Beta-Tricalcium Phosphate Granules for Cultured Osteoblast-like Cells
  • Author(s): Yamada M, Minamikawa H, Ueno T, Sakurai K, Ogawa T
  • Journal Title: J Biomater Appl. Volume: (In press)
  • DOI: doi:10.1177/0885328210383598
  • Peer Reviewed
• [Presentation] 組織再生を促す抗酸化アミノ酸誘導体による生体材料の多機能化 (2011)
  • Author(s): 山田将博
  • Organizer: 第64回日本酸化ストレス学会学術集会シンポジウム
  • Place of Presentation: 北海道
  • Year and Date: 2011-07-03
• [Presentation] Amino-acid Derivative-mediated Multifunctionalization of Biomaterial for BoneRegeneration (2010)
  • Author(s): Yamada M.
  • Organizer: BIT Life Sciences' 8th Annual Congress of International Drug Discovery Science and Technology
  • Place of Presentation: Beijing、China
  • Year and Date: 2010-10-24
• [Presentation] Amino Acid-derivative Mediated Multifunctionalization of PMMA and Bone Substitute (2010)
  • Author(s): Yamada M.
  • Organizer: The 88th General Session and Exhibition of the IADR
  • Place of Presentation: Barcelona、Spain
  • Year and Date: 2010-07-15
• [Book] インプラント周囲炎を治療する-エビデンスに基づく診断・治療とリスクコントロール- (2011)
  • Author(s): 山田将博, 他
  • Total Pages: 221
  • Publisher: 医学情報社
• [Remarks] 東京歯科大学HRCプロジェクト研究HRC第8プロジェクト・免疫機能・トランスレーショナル研究グループホームページ
  • URL: http://www.tdc.ac.jp/dept/osc/hrc8/hrc8g2ac.html
• [Remarks] 東京歯科大学有床義歯補綴学講座ホームページ
  • URL: http://www.tdc.ac.jp/dept/rpg/