Study on the function of autophagy and ubiquitin- proteasome systems in the atrophy of tongue and masticatory muscles induced by aging

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791912
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Tsurumi University
• Principal Investigator: IIDA Ryohei 鶴見大学, 歯学部, 助教 (70339810)
• Project Period (FY): 2010 – 2012
• Keywords: 顎口腔機能学 / 摂食・嚥下機能障害

Research Abstract

In the present study, the mechanism for sarcopenia was explored. The activity of masticatory and tongue muscles such as protein degradation was more active than limb and trunk muscles in aged mice. The influence of aging varied among masticatory and tongue muscles.

Research Products

• [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, abeta2-adrenergic agonist. (2012)
  • Author(s): ABO, T., IIDA, R., KANEKO, S., SUGA, T., YAMADA, H., HAMADA, Y. and YAMANE, A.
  • Journal Title: Cell Biochem. Func. Volume: 30(8) Pages: 671-676
  • Peer Reviewed
• [Journal Article] Changes in triacylglycerol-accumulated fiber type, fiber type composition (2011)
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., FUKUI, T., MORITO, M. and YAMANE, A.
  • Journal Title: biogenesis in the mitochondria of the soleus muscle in obese rats. Anat. Volume: Rec. 294 (11) Pages: 1904-1912
  • Peer Reviewed
• [Journal Article] Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse a mouse model for aging. (2011)
  • Author(s): IIDA, R., KANEKO, S., SUGA, T., MORITO, M. and YAMANE, A.
  • Journal Title: Mol. Cell. Biochem. Volume: 348(1) Pages: 89-98
  • Peer Reviewed
• [Journal Article] TGFb3 is expressed in differentiating muscle of the embryonic mouse tongue. (2010)
  • Author(s): YAMANE, A., FUKUI, T., SUGA, T., IIDA, R. and MORITO, M.
  • Journal Title: Int. J. Dev. Volume: Biol.54(1):221-226
  • Peer Reviewed
• [Journal Article] BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-13. (2010)
  • Author(s): FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y. and YAMANE, A.
  • Journal Title: Anat. Rec Volume: 293(8) Pages: 1408-1415
  • Peer Reviewed
• [Journal Article] Klotho 遺伝子突然変異マウス骨格筋におけるインスリン様増殖因子およびその受容体 mRNA 発現. (2010)
  • Author(s): 飯田良 平 、菅 武雄、山根 明、森戸光彦.
  • Journal Title: 鶴見歯学 Volume: 36(2) Pages: 95-102
  • Peer Reviewed
• [Journal Article] Age-related changes in rat genioglossus, geniohyoid, and masseter muscles.
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., MORITO, M. and YAMANE, A.
  • Journal Title: Gerodontology Volume: (in press)
  • Peer Reviewed