2011 Fiscal Year Final Research Report
Development of adhesive nano-hydroxyapatite-collagen composite
| Project/Area Number |
22791917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
TENKUMO Taichi 北海道大学, 大学院・歯学研究科, 専門研究員 (80451425)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 歯周組織 / ナノハイドロキシアパタイト / BMP2 / 弾性 |
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| Research Abstract |
Implantation of a nHAC membrane that was loaded with low dose of BMP-2 and placed on dentin chips, into rat thigh muscle, resulted in the formation of a long thin, cementum-like hard tissue on the dentin surface at an early stage after implantation without increasing dentin resorption. On the other hand, the nHAC, cross-linked by EDC and added fibrin glue has more elastic. This new material showed a good biocompatibility and biodegradability in vivo. nHAC-fibrin composite with BMP-2 resulted in ectopic bone formation in rat thigh muscle, and showed to be suitable as the carrier of BMP-2.
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