2011 Fiscal Year Final Research Report
Effective of a novel cholesterol-bearing pullulan nanogel membrane for guided bone regeneration
| Project/Area Number |
22791925
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 再生歯学 |
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| Research Abstract |
Cholesterol-bearing pullulan(CHP) nanogel is a synthetic degradable biomaterial for drug delivery with high biocompatibility. The purpose of this study was to evaluate the effects of the CHP nanogel membrane in guided bone regeneration(GBR). As a result of micro-CT analysis, new bone formation in terms of bone volume was higher in the nanogel group than in the control or collagen groups at 2 and 4 weeks. Histologically, new bone formation in CHP nanogel was prominent at 2 and 4 weeks compared with the other two groups. Notably, newly-formed bone in the CHP nanogel group was mature bone. The results of this study suggest that CHP nanogel membrane would be potentially effective as a GBR membrane.
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