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2011 Fiscal Year Final Research Report

Influence of trkB gene polymorphism on BDNF-induced periodontal tissue regeneration

Research Project

  • PDF
Project/Area Number 22791929
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionHiroshima University

Principal Investigator

KATSUHIRO Takeda  広島大学, 医歯薬学総合研究科, 助教 (10452591)

Project Period (FY) 2010 – 2011
Keywords再生歯学
Research Abstract

We planned to clarify the characteristics of BDNF-induced periodontal tissue regeneration, and to investigate the genetic association of trkB with periodontal tissue regeneration by BDNF. In vitro study, two weeks after the BDNF application, periodontal tissue regeneration was insufficient, but invasion of epithelial cells to defects was not observed. TrkB, PCNA and OPN-positive cells were detected on the denuded root surface, around the regenerating alveolar bone and in the soft connective tissue of regenerating periodontal tissues. TrkB positive cells may quickly responded to applied BDNF and started to proliferate and differentiate for the periodontal tissue regeneration within 2 weeks. Furthermore, we investigated the trkB single nucleotide polymorphisms(SNPs) which are reported to have some relationships with Alzheimer' s disease.

  • Research Products

    (9 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Brain-derived neurotrophic factorinduces migration of endothelial cellsthrough a TrkB-ERK-integrinα(V)β(3)-FAK cascade2011

    • Author(s)
      Matsuda S, Fujita T, Kajiya M, Takeda K, Shiba H, Kawaguchi H, Kurihara H
    • Journal Title

      J CellPhysiol

    • Peer Reviewed
  • [Journal Article] Characteristics of High-Molecular-Weight Hyaluronic Acidas a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration2011

    • Author(s)
      Takeda K, Sakai N, ShibaH, Nagahara T, Fujita T, Kajiya M, Iwata T, Matsuda S, Kawahara K, Kawaguchi H, Kurihara H
    • Journal Title

      Tissue EngPart A

      Volume: 17(7-8) Pages: 955-67

    • Peer Reviewed
  • [Journal Article] The antimicrobial peptide LL37 inducesthe migration of human pulp cells : apossible adjunct for regenerative endodontics2010

    • Author(s)
      Kajiya M, Shiba H, Komatsuzawa H, Ouhara K, Fujita T, Takeda K, Uchida Y, Mizuno N, Kawaguchi H, Kurihara H
    • Journal Title

      J Endod

      Volume: 36(6) Pages: 1009-13

    • Peer Reviewed
  • [Journal Article] The expressions of claudin-1 andE-cadherin in junctional epithelium2010

    • Author(s)
      Fujita T, Hayashida K, Shiba H, Kishimoto A, Matsuda S, Takeda K, Kawaguchi H, Kurihara H
    • Journal Title

      J PeriodontalRes

      Volume: 45(4) Pages: 579-82

    • Peer Reviewed
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発2011

    • Author(s)
      武田克浩、柴秀樹、藤田剛、松田真司、小西昭弘、片桐菜穂子、河口浩之、栗原英見
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-01
  • [Presentation] Brain-derived Neurotrophic Factor/ Hyaluronic Acid Complex Enhances Periodontal Tissue Regeneration2010

    • Author(s)
      K. Takeda, H. Shiba, H. Kawaguchi, H. Kurihara
    • Organizer
      The Korean Academy of Periodontology. The 50^th Anniversary and International Congress of Scientific Meeting
    • Place of Presentation
      ソウル、韓国
    • Year and Date
      2010-11-28
  • [Presentation] 脳由来神経栄養因子(BDNF)はヒト歯肉線維芽細胞のTrkBを介してヒアルロン酸合成酵素発現を促進する2010

    • Author(s)
      片桐菜穂子, 武田克浩, 柴秀樹, 小西昭弘, 橘高瑞穂, 藤田剛, 松田真司, 河口浩之, 栗原英見
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      香川
    • Year and Date
      2010-09-19
  • [Presentation] 脳由来神経栄養因子(BDNF)は血管内皮細胞遊走過程におけるintegrinの発現、及びFocal adhesion kinase(FAK)のリン酸化を制御する2010

    • Author(s)
      松田真司, 藤田剛, 加治屋幹人, 武田克浩, 柴秀樹, 河口浩之, 栗原英見
    • Organizer
      第53回日本歯周病学会学術大会(春季)
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-14
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発-根面処理併用効果の検討-2010

    • Author(s)
      小西昭弘、武田克浩、柴秀樹、林田浩一、橘高瑞穂、藤田剛、松田真司、河口浩之、橋本正道、辻紘一郎、栗原英見
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18

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Published: 2013-07-31  

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