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2011 Fiscal Year Final Research Report

Development of the new cell therapy for a neurologic and muscular disorder : considering the possibility of the cell source of the periodontal membrane

Research Project

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Project/Area Number 22791943
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

TOMINAGA Noriko  日本歯科大学, 生命歯学部, 助教 (90546532)

Project Period (FY) 2010 – 2011
Keywords再生歯学
Research Abstract

The muscle and nerve cells(neurons) were isolated from rat periodontal ligament cells. The muscle cells were confirmed by patch-clamp method, their action potential were similar to the skeletal muscle cells or the cardiac muscle. In immunostaining, there are positive cells for the skeletal muscle marker, toroponin T ; or the myocardial marker, toroponin I ; or the smooth muscle marker,α-smooth muscle action. In the evaluation of bone differentiation potential, the formation of calcification nodule were formed in the fibroblast from primary culture of periodontal ligament. But almost none of such calcification was observed in muscle cells and neurons.

  • Research Products

    (7 results)

All 2011 2010

All Journal Article (3 results) Presentation (4 results)

  • [Journal Article] 口のふしぎと歯のふしぎ親知らずを抜くことを勧められましたが、抜きたくありません。抜いた親知らずは、何かの役に立ちませんか?2011

    • Author(s)
      富永徳子
    • Journal Title

      DHstyle

      Volume: 5 Pages: 14-15

  • [Journal Article] Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma : Special reference to the susceptibility of anti-cancer drugs2010

    • Author(s)
      Suzuki M, Tominaga N, Ide Y, Ohyama A, Nakahara T, Ishikawa H, Tanaka A, Mataga I
    • Journal Title

      Human cell

      Volume: 23(2) Pages: 65-73

  • [Journal Article] 抜去歯由来の幹細胞にみる再生医療の未来2010

    • Author(s)
      中原貴, Nikolay Ishkitiev, 富永徳子, 井出吉昭
    • Journal Title

      日本歯科医師会雑誌

      Volume: Vol.62 No.12 Pages: 21-29

  • [Presentation] 抜去歯の新たな使い道-再生医療にむけて2011

    • Author(s)
      富永徳子
    • Organizer
      平成23年東京都歯科医師会卒後研修会
    • Place of Presentation
      東京
    • Year and Date
      20110700
  • [Presentation] 再生医療における歯根膜細胞の細胞源としての可能性2010

    • Author(s)
      富永徳子, 中原貴
    • Organizer
      日本歯科大学歯学会研究推進フォーラム
    • Place of Presentation
      東京
    • Year and Date
      20100900
  • [Presentation] Establishing HGCT cell lines derived from germ cell tumors of human ovary and production of IL-1., IL-6 and VEGF2010

    • Author(s)
      富永徳子, 井出吉昭, 安田充, 鈴木美奈子, 那須優則, 石川博, 中原貴
    • Organizer
      第28回日本ヒト細胞学会学術集会
    • Place of Presentation
      茨城
    • Year and Date
      20100800
  • [Presentation] 歯根膜細胞の再生医療にむけた自家細胞ソースとしての可能性2010

    • Author(s)
      富永徳子
    • Organizer
      平成22年度OMSTアカデミア学術発表
    • Place of Presentation
      東京
    • Year and Date
      20100400

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Published: 2013-07-31  

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