2011 Fiscal Year Final Research Report
Elucidation of epigenetic abnormalities which lead oral malignancy from oral premalignant lesion
| Project/Area Number |
22791955
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Masanobu 東京大学, 医学部附属病院, 助教 (10392333)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 臨床腫瘍学 |
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| Research Abstract |
324 of highly methylated genes at promoter region were identified by MeDIP-CGI microarray assay in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2). Furthermore, the global expression levels between before and after 5-aza-dC treatment in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2) were analyzed and 351 of highly up-regulated genes by the treatment were identified. Finally, 125 of silencing genes by promoter methylation were identified in oral squamous cell carcinoma cell lines.
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