Effects of angiogenesis inhibitor and fibroblast growth inhibitor on invasion and metastasis of oral squamous cell carcinoma.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791967
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kanazawa University
• Principal Investigator: NOGUCHI Natsuyo 金沢大学, 附属病院, 医員 (90547176)
• Project Period (FY): 2010 – 2011
• Keywords: 口腔扁平上皮癌 / 増殖抑制 / 線維芽細胞増殖抑制剤 / シスプラチン / 血管新生阻害剤 / 浸潤 / 転移

Research Abstract

Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and fibroblast growth inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OLC-01, was implanted into the tongue of nude mice, and cisplatin or tranilast were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasis were investigated. Tumor sizes and stromal collagen fiber volumes were significantly reduced in conbination group of cisplatin and tranilast. And tumor stromas were changed properties in conbination group. The use of anticancer agent and fibroblast growth inhibitor considering these effects may be clinically very useful.

Research Products

• [Journal Article] Expression form of p53 andPCNA at the invasive front in oral squamous cell carcinoma : correlation with clinicopathological features and prognosis (2011)
  • Author(s): Kato K, Kawashiri S, Yoshizawa K, Kitahara H, Okamune A, Sugiura S, Noguchi N, Yamamoto E.
  • Journal Title: Journal of Oral Pathologyand Medicine Volume: 40 Pages: 693-698
  • DOI: DOI:10.1111/j.1600-0714.2011.01032.x
  • Peer Reviewed
• [Journal Article] Expression of urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor and maspin in oral squamous cell carcinoma : Association with mode of invasion and clinicopathological factors. (2011)
  • Author(s): Yoshizawa K, Nozaki S, Kitahara H, KatoK, Noguchi N, Kawashiri S, Yamamoto E.
  • Journal Title: OncologyReport Volume: 26 Pages: 1555-1560
  • DOI: DOI:10.3892/or.2011.1419
  • Peer Reviewed
• [Journal Article] Expression of Hypoxia-Inducible Factor-1 Alpha in oral squamous cell carcinoma (2010)
  • Author(s): Noguchi N, Kawashiri S, Kato K, Yoshizawa K, Kitahara H, Yamamoto E.
  • Journal Title: XX Congress of the European Associationof Cranio-Maxillo-Facial Surgery Volume: 1 Pages: 53-57
• [Journal Article] 口腔扁平上皮癌における臨床ならびに病理組織学的所見と予後との関係 (2010)
  • Author(s): 川尻秀一、加藤広禄、野口夏代、吉澤邦夫、北原寛子、山本悦秀
  • Journal Title: 石川県歯科医師会歯科学報 Volume: 1 Pages: 9-13
• [Presentation] 口腔扁平上皮癌における接着分子としてのCD44v3の発現と臨床病理組織学的因子との関係 (2012)
  • Author(s): 杉浦史郎、加藤広禄、野口夏代、吉澤邦夫、北原寛子、岡宗絢子、八木瑞希、木村依世、吉本泰祐、川尻秀一
  • Organizer: 第30回日本口腔腫瘍学会学術集会
  • Place of Presentation: 大宮ソニックシティー(埼玉)
  • Year and Date: 2012-01-26
• [Presentation] Evaluation of clinical and histopathological factors for survival in squamous cell carcinoma of oral cavity. (2011)
  • Author(s): Kawashiri, S., Noguchi, N., Kato, K., Yoshizawa, K., Kitahara, H., Okamune, A., Sugiura, S., Yamamoto, E.
  • Organizer: 20th International Conference of Oral and Maxillofacial Surgery
  • Place of Presentation: Casa Piedra Centrode Eventos Congresos, Santiago(Chile)
  • Year and Date: 2011-11-03
• [Presentation] E-Cadherinの口腔扁平上皮癌の浸潤への影響 (2011)
  • Author(s): 北原寛子,川尻秀一,野口夏代,加藤広禄,吉澤邦夫,岡宗絢子,山本悦秀
  • Organizer: 第35回日本頭頸部癌学会
  • Place of Presentation: ウインクあいち(愛知県)
  • Year and Date: 2011-06-10
• [Presentation] 口腔扁平上皮癌における接着分子としてのCD44の発現 (2011)
  • Author(s): 杉浦史郎,川尻秀一,加藤広禄,野口夏代,吉澤邦夫,北原寛子,岡宗絢子,八木瑞希,木村依世,山本悦秀
  • Organizer: 第65回日本口腔科学会学術集会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2011-04-22
• [Presentation] uPA, uPAR and Maspin expression as abiomarker in invasive oral squamous cellcarcinoma (2011)
  • Author(s): Yoshizawa K, Kawashiri S, Kitahara H, Kato K, Noguchi N, Yamamoto E
  • Organizer: 3rd International Conferenceon Innovative Approach in Head & Neck Oncology
  • Place of Presentation: Palau de Congressosde Catalunya Barcelona(Spain)
  • Year and Date: 2011-02-25
• [Presentation] 吉澤邦夫,能崎晋一,八木瑞希,木村依世,杉浦史郎,岡宗絢子,北原寛子,加藤広禄,野口夏代,川尻秀一,中川清昌,山本悦秀 (2011)
  • Author(s): 吉澤邦夫,能崎晋一,八木瑞希,木村依世,杉浦史郎,岡宗絢子,北原寛子,加藤広禄,野口夏代,川尻秀一,中川清昌,山本悦秀
  • Organizer: 第29回日本口腔腫瘍学会総会
  • Place of Presentation: 崇城大学市民ホール(熊本県)
  • Year and Date: 2011-01-27
• [Presentation] AMPK活性化薬剤による口腔扁平上皮癌の細胞増殖抑制効果の検討 (2010)
  • Author(s): 加藤広禄,川尻秀一,木村依世,八木瑞希、杉浦史郎,岡宗絢子,北原寛子,吉澤邦夫,野口夏代,山本悦秀
  • Organizer: 第55回日本口腔外科学会総会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2010-10-18
• [Presentation] Expression of Hypoxia-Inducible Factor-1 Alpha in oral squamous cellcarcinoma (2010)
  • Author(s): Noguchi, N., Kawashiri, S., Kato, K., Yoshizawa, K., Kitahara, H., Yamamoto, E
  • Organizer: XX Congress of the European Association of Cranio-Maxillo-Facial Surgery
  • Place of Presentation: Concert gebouw(Belgium)
  • Year and Date: 2010-09-14
• [Presentation] 口腔扁平上皮癌における予後予測因子の検討 (2010)
  • Author(s): 川尻秀一,野口夏代,加藤広禄,吉澤邦夫,山本悦秀
  • Organizer: 第64回日本口腔科学会総会
  • Place of Presentation: 札幌プリンスホテル国際館パミール(北海道)
  • Year and Date: 2010-06-24