2011 Fiscal Year Final Research Report
Molecular targeting therapy targeting for inhibition of metastasis on oral squamous cell carcinoma
| Project/Area Number |
22791972
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口腔癌 / 分子標的治療 |
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| Research Abstract |
An important tool of cancer therapy in 21th century is a molecular targeting therapy. However there are a little studies to focused on distant metastasis and lymph node metastasis which occur frequently on oral squamous cell carcinoma. Combinations of safingol, which induced apoptosis caspase independent manner and GGTI-298, new molecular target drug, exhibited synergistic effect. GGTI-298 and safingol inhibited cell growth synergistically and increased the number of apoptotic cells. Combination of safingol and GGTI-298 may be a candidate for the treatment of oral SCC targeting for anticancer drug resistance and suppression of metastasis because safingol have antitumor effect and GGTI-298 suppress metastasis.
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