2011 Fiscal Year Final Research Report
The exhaustive analysis of proteins related with STAT signaling and the possibilities for new treatments of oral cancer patients
| Project/Area Number |
22791987
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
ISHIKAWA Akiko 愛媛大学, 大学院・医学系研究科, 講師 (90444760)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口腔癌 / STAT / 細胞間接着 / E-カドヘリン |
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| Research Abstract |
STAT signaling is activated by E-cadherin binding following cell-cell adhesions, which lead the avoidance of cancer cells death. This study showed that both Rac1 and Cdc42 were phosphorylated after cell-cell adhesions. As the result of STAT3 inhibition by using siRNA, STAT3 activation promotes cancer cell activity by avoiding cells death, but little affects cell growth, migration and invasion.
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