2012 Fiscal Year Final Research Report
Molecular biological study on the pathogenesis of a novel clinical entity, Mikulicz's disease/ IgG4-related diseas
| Project/Area Number |
22791990
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | IgG4関連疾患 / ミクリッツ病 / Thサブセット / サイトカイン |
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| Research Abstract |
Mikulicz’s disease (MD) shows a high-frequency GCs formation in the salivary glands. Recent studies reported that IL-21 mainly produced by T follicular (Tfh) cells is provided help to germinal centers (GCs) formation and involved in a class switching of IgG4. In this study, we thus examined the expression of IL-21 in MD and Sjogren’s syndrome (SS) patients. As the results, IL-21 and CXCR5 were detected in/around GCs from both SS and MD patients. Interestingly, IL-21 was also detected in infiltrating lymphocytes outside GCs from only MD patients. The expression of Th2-related molecules was similar to that of IL-21, while IL-17 was rarely seen in MD. Furthermore, the expression of IL-21 in the LSGs was correlated with the IgG4/IgG ratio in MD. These results suggest that overexpression of IL-21 by Th2 cells might play a key role in GCs formation and IgG4 production in MD
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Research Products
(20 results)
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[Journal Article] Validation of different sets of criteria for the diagnosis of Sjogren's syndrome in Japanese patients2012
Author(s)
Tsuboi H, Hagiwara S, Asashima H, Umehara H, Kawakami A, Nakamura H, Sano H, Tsubota K, Ogawa Y, Takamura E, Saito I, Inoue H, Nakamura S, Moriyama M, et al
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Journal Title
Mod Rheumatol
Volume: (in press)
Peer Reviewed
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