2011 Fiscal Year Final Research Report

Analysis of stem/progenitor cell in human irradiated salivarygland

Research Project

Project/Area Number	22791999
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Yokohama City University
Principal Investigator	SATO Yuki 横浜市立大学, 医学研究科, 共同研究員 (60573277)
Research Collaborator	HIROTA Makoto 横浜市立大学, 医学部, 准教授 (20347305)
Project Period (FY)	2010 – 2011
Keywords	唾液腺 / 放射線 / 幹細胞
Research Abstract	The salivary gland stem/progenitor cells were examined using the irradiated human salivary gland cells and human salivary-glands cancer cell line. In the irradiated-salivary gland tissue, salivary gland stem cell was not isolated stably. Sarivary gland cancer cell line showed proliferation with re-multidifferentiation. Furthermore, the salivary-glands amylase activity at the time of invasion was measured immunohistologically, salivary-glands amylase activity went up at the time of invasion, indicating that amylase activity was involving closely the activity dynamic state of a salivary-glands stem/progenitor cell.

(1 results)