2011 Fiscal Year Final Research Report
Analysis of stem/progenitor cell in human irradiated salivarygland
| Project/Area Number |
22791999
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
SATO Yuki 横浜市立大学, 医学研究科, 共同研究員 (60573277)
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| Research Collaborator |
HIROTA Makoto 横浜市立大学, 医学部, 准教授 (20347305)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 唾液腺 / 放射線 / 幹細胞 |
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| Research Abstract |
The salivary gland stem/progenitor cells were examined using the irradiated human salivary gland cells and human salivary-glands cancer cell line. In the irradiated-salivary gland tissue, salivary gland stem cell was not isolated stably. Sarivary gland cancer cell line showed proliferation with re-multidifferentiation. Furthermore, the salivary-glands amylase activity at the time of invasion was measured immunohistologically, salivary-glands amylase activity went up at the time of invasion, indicating that amylase activity was involving closely the activity dynamic state of a salivary-glands stem/progenitor cell.
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