2011 Fiscal Year Final Research Report
Examination of central pain suppression in a facial cancer model
| Project/Area Number |
22792005
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
HARANO Nozomu 九州歯科大学, 歯学部, 助教 (50423976)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Kentarou 九州歯科大学, 歯学部, 准教授 (40316154)
INENAGA Kiyotoshi 九州歯科大学, 歯学部, 教授 (90131903)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口腔顔面癌 / 癌性疼痛 / 三叉神経脊髄路核尾側亜核 / アストロサイト / ミクログリア |
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| Research Abstract |
Glial activation in the central nervous system, but not in the peripheral nervous system, mediates the enhancement of spontaneous pain and the development of allodynia and hyperalgesia at an early stage in the facial cancer model. And central glial hyperactivation, transient microglial hyperactivation and persistent astrocytic hyperactivation, contributes to the development of pain hypersensitivity but not to the maintenance of pain in this model.
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