2012 Fiscal Year Final Research Report
Can sphingosine-1-phosphate control bisphosphonate-mediated bone formation?
| Project/Area Number |
22792009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ABE Takahiro 東京大学, 医学部附属病院, 特任講師 (20383250)
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| Project Period (FY) |
2010 – 2012
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| Keywords | S1P / ビスホスホネート / 骨芽細胞 / 間葉系幹細胞 |
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| Research Abstract |
The jawbone necrosis caused by bisphosphonate (BP) is a globally recognized adverse effect of BP treatment. In 2008, the Japanese Society of Oral and Maxillofacial Surgeons defined guidelines for prevention, diagnosis, and medical treatment of this adverse effect, and obtained consensus for these guidelines in Japan. However, many aspects related to the morbidity of this condition have not been clarified, and there are no instructions for medical treatment. A recent study showed that sphingosine-1-phosphate (S1P) participates in bone remodeling regulation. Although we have shown experimentally that RANKL/OPG imbalance was produced by adding risk factors to BP, the aim of this study was to verify whether S1P further influences BP-mediated bone remodeling.
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Author(s)
Sato T, Nakamoto A, Hori N, Enoki Y, Fukushima Y, Nakamoto N, Sakata Y, Yamanaka H, Chida D, Abe T, Yoda T.
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Journal Title
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
Volume: 24(4)
Pages: 185-188
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[Journal Article] Preliminary results of a study comparing conventional radiography with phase-contrast radiography for assessing root morphology of mandibular third molars.2011
Author(s)
Sato T, Nakamoto N, Abe T, Fukushima Y, Tomaru Y, Sakata Y, Nakazawa M, Nakamoto A, Kawasaki H, Wada Y, Ohara H, Araki R, Tanaka J, Yoda T.
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Journal Title
Dentomaxillofac Radiol.
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[Journal Article] Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts.2010
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Sato T, Abe T, Chida D, Nakamoto N, Hori N, Kokabu S, Sakata Y, Tomaru Y, Iwata T, Usui M, Aiko K, Yoda T.
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Journal Title
FEBSLetters
Volume: 584
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[Presentation] 当科における生体内吸収性PLLA/HA骨接合プレート(Super Fixsorb)治療成績とその合併症.2012
Author(s)
瀬戸一郎,森良之,西條英人,古賀陽子,安部 貴大,末永英之,阿部雅修,菅野勇樹,杉山円,星和人,高戸毅
Organizer
第57回日本口腔外科学会総会
Place of Presentation
パシフィコ横浜会議センター,横浜
Year and Date
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森良之,末永英之,阿部雅修,古賀陽子,菅野勇樹,杉山円,安部貴大,瀬戸一郎,西條英人,星和人,高戸毅
Organizer
第57回日本口腔外科学会総会
Place of Presentation
パシフィコ横浜会議センター,横浜
Year and Date
20121019-21
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[Presentation] 完全両側性唇顎口蓋裂患者の顎顔面形態・咬合の成長による変化と顎矯正手術の必要性.2012
Author(s)
岡安麻里,須佐美隆史,井口隆人,内野夏子,上床喜和子,森良之,西條英人,安部 貴大,古賀陽子,末永英之,大久保和美,高戸毅
Organizer
第22回日本顎変形症学会総会
Place of Presentation
福岡国際会議場,福岡
Year and Date
20120618-19
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[Presentation] 東京大学医学部附属病院顎口腔外科における歯原性腫瘍の統計的観察.2012
Author(s)
阿部達也, 安部 貴大,古賀陽子,阿部雅修,末永英之,菅野勇樹,杉山円,瀬戸一郎,星和人,西條英人,森良之,高戸毅
Organizer
第66回 日本口腔科学会学術集会
Place of Presentation
広島国際会議場, 広島
Year and Date
20120517-18
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[Presentation] Nanog promotes osteogenic differentiation of mesenchymal cells by modulating bone morphogenetic protein (BMP) signaling.2011
Author(s)
Ogasawara T, Ohba S, Yano F, Kawaguchi H, Abe T, Takato T, Hoshi K.
Organizer
2011 annual meeting of the American Society for Bone and Mineral Research, September 16-20
Place of Presentation
San Diego, California, USA, San Diego Convention Center
Year and Date
20110000
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