2011 Fiscal Year Final Research Report
Telomerase-Specific Replication-Selective Virotherapy combined with radiation therapy for oral squamous cell carcinoma cells.
| Project/Area Number |
22792013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口腔癌 / ウイルス治療 / 放射線治療 |
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| Research Abstract |
We describe the mechanistic basis for synergy of irradiation and virotherapy. This combination therapy was more effective compared with Telomelysin alone in OSCC cells. These results illustrate the potential of combining oncolytic virotherapy and ionizing radiation as a promising strategy in the management of human oral cancer.
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