2011 Fiscal Year Final Research Report
Analysis of oral cancer growth inhibitory mechanism of molecular targeted therapy
| Project/Area Number |
22792014
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Showa University |
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Principal Investigator |
|
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| Project Period (FY) |
2010 – 2011
|
| Keywords | 口腔癌 / 分子標的治療 / STAT3 |
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| Research Abstract |
We describe the mechanistic basis for STAT3 inhibitor(JSI-124) that we found the efficacy for oral cancer cells. Administration of JSI-124 suppresses OSCC growth through apoptosis. Additionally, we observed that the growth of xenograft SAS tumors in nude mice was significantly blocked by the administration of JSI-124 without major adverse effects.
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