2011 Fiscal Year Final Research Report
Mutation in 10 Gene are the Genetic Factor for Nonsyndromic Cleft Lip and/or Cleft Palate
| Project/Area Number |
22792018
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口唇裂・口蓋裂 / 候補遺伝子 / SNP / 変異解析 / 相関解析 / TDT検定 / 連鎖不平衡 / DNA |
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| Research Abstract |
We performed mutation analysis of 10 genes(RYK(3q22)、EPHB2(1p36.1-35)、EPHB3(3q28-27)、DLX3(17q23)、TBX10(11q13.1)、TGF-B3(14q24)、PAX9(14q12-q13)、CLPTM1(19q13.2)、PVRL1(11q23)、TBX22(Xq21.1)), case-control study, TDT(transmission disequilibrium test) in the parents with the patients with cleft lip and/or cleft palate. We found a gene associated with the appearance of disease of cleft lip and/or cleft palate.
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