2011 Fiscal Year Final Research Report
The effect of Del-1 by in vivo gene therapy
| Project/Area Number |
22792019
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 癌 / 遺伝子 / 蛋白質 |
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| Research Abstract |
A nude mouse was injected an oral squamous cell carcinoma cell line : SCCKN at the subcutaneously back and made a transplant tumor. The transplant tumor was treated by the gene therapy of pFasL or pFasL/E3D1 gene. The pFasL or pFasL/E3D1 gene was injected every week. The all mice of control group and/or treated of pFasL gene group were dead of 49^<th> days. But, the survival rate of mice with treated by pFasL/E3D1 was 87% at 49^<th> days. It was confirmed that the dosage of pFasL/E3D1 controls the increase of tumor, and there is a survival benefit in a transplant tumor.
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