2012 Fiscal Year Final Research Report
Analysis for pathogeny and healing of trigeminal neuropathic pain model rats
| Project/Area Number |
22792024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経因性疼痛 / モデルラット / 延髄 / マイクログリア |
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| Research Abstract |
Four models of trigeminal nerve injury were tested for mechanical threshold on whisker pad. The mechanical allodynia was induced in all “infraorbital nerve ligation model” rats, but in only the half of “inferior alveolar nerve transaction model” rats. Therefore, another half of “inferior alveolar nerve transaction model” rat did not develop the mechanical allodynia. However, neither alterations of gene expression in trigeminal ganglion that indicate the nerve injury, nor microglial activation in the medullary dorsal horn that thought to be closely related to the pathogenic mechanism of allodynia, had a correlation with the occurrence of allodynia.
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