2012 Fiscal Year Final Research Report
The role for the stress protein in regulation of development of themandibular condylar cartilage by mechanical stress
| Project/Area Number |
22792064
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Kyushu Dental College |
|---|
Principal Investigator |
FUJITA Yuko 九州歯科大学, 歯学部, 助教 (90514670)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 小児歯科 |
|---|
| Research Abstract |
This study investigated the localization and expression of heme oxygenase (HO)-1, type II and X collagen (Col10 and 2) and matrix metalloproteinase (MMP)-13 proteins in mouse mandibular condylar cartilage and mouse tibial cartilage. C57BL/6J mice aged 1, 7, 14, 21 and 49 days were subjected to using immunohistochemistry. This study demonstrated that HO-1 is the protein which expresses specifically to early stages of the development, in particular under hypoxia environment in chondrocytes. These findings suggest that HO-1 is involved in the process of the endochondral ossification from a blood vessel invasion in hypertrophic chondrocytes and acts as a regulatory factor in the early stages of the development of condylar cartilage.
|
