2012 Fiscal Year Final Research Report
DNA chip analysis and identification of the genes induced in human periodontalligament to cause tooth root resorption.
| Project/Area Number |
22792065
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Health Sciences University of Hokkaido |
|---|
Principal Investigator |
OKAYAMA Miki 北海道医療大学, 歯学部, 助教 (30382500)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | メカニカルストレス / 歯根膜 / 歯の移動 / 歯根吸収 |
|---|
| Research Abstract |
ID1 (Inhibitor of DNA binding 1), EGR1 (Early growth response 1), SGK1 (Regulator of G-protein signaling 2) and DUSP1 (Dual specificity phosphatase 1) were upregulated in 2 hours by 7G-loading in human PDL cells. U0126, MEK inhibitor diminished up-regulation and phosphorylation of these genes. Thus, the phosphorylation of ERK had crucial rule in genes induced by mechanical stress. It was also suggested that the mechanical stress controlled remodeling of periodontal tissues and tooth root resorption through extracellular matrix degradation.
|
