2012 Fiscal Year Final Research Report
Elucidation of molecular mechanism in aplastic of cranial base synchondrosis through the hedgehog signaling pathway.
| Project/Area Number |
22792074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
TAKANAGA Ochiai 松本歯科大学, 歯学部, 口腔病理学講座助教 (20410417)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯科矯正学 |
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| Research Abstract |
We examine that chondrocyte influence due to the abnormal Indian hedgehog pathway which was important to chondrocyte differentiation. We elucidated a production decrease in heparan sulfate proteoglycan which was an extra-celler matrix by the abnormality of the Indian hedgehog pathway. Furthermore, we elucidated that heparan sulfate proteoglycan was combined with an Indian hedgehog protein. These results suggest that heparan sulfate proteoglycan might be controlled in the cartilage differentiation through Indian hedgehog pathway.
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