2011 Fiscal Year Final Research Report
The molecular mechanism of soft palate development
| Project/Area Number |
22792076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
OKA Kyoko 福岡歯科大学, 歯学部, 講師 (60452778)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 口蓋裂 / 軟口蓋 / TGF-betaシグナル |
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| Research Abstract |
The experiment was performed for understanding of the mechanism of soft palate development. We demonstrated a unique pattern of periostin expression during soft palate development, which was closely related to that of collagen type I(Col I) in palatine aponeurosis. Furthermore, organ culture analysis showed that exogenous transforming growth factor-β(TGF-b) induced the expression of both periostin and Col I. TGF-b signaling appears to be one of the mediators of Col I and periostin expression in the formation of functional structures during soft palate development.
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