2011 Fiscal Year Final Research Report
Analysis of the mechanism of FGF-2 enhancement induced by extracellular calcium in cementoblasts
| Project/Area Number |
22792079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | セメント芽細胞 / 細胞外カルシウム / PMA / FGF-2 |
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| Research Abstract |
We found that extracellular calcium increases fibroblast growth factor-2 expression levels via a cAMP/Protein kinase A dependent pathway in cementoblasts. We also found that Phorbol 12-myristate 13-acetate (PMA), the potent stimulator of Protein kinase C increases FGF-2 expression in cementoblasts. These indicate the presence of different pathways for FGF-2 enhancement in cementoblasts.
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