2012 Fiscal Year Final Research Report
Possible Mechanisms of Progression of Periodontal Disease by TACE-Timp3 Interaction in Patients with Diabetes Mellitus
| Project/Area Number |
22792083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
OMORI Kazuhiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20549860)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯周病 / 糖尿病 / 慢性炎症 / シェディング |
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| Research Abstract |
Periodontal disease in poor controlled-diabetic patients has very severe inflammation. In the present study, hyperglycemia enhanced TACE activity and MMP-3 production in human gingival fibroblasts. In addition, recombinant activated MMP-3 enhanced the shedding of soluble IL-6 receptor in macrophage-like differentiated THP-1. These results suggest that hyperglycemia-induced facilitation of TACE and MMP-3 in gingival fibroblasts/macrophage interaction induce severe periodontal inflammation through enhancement of IL-6 signaling in the patients with poor controlled-diabetic mellitus.
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