2012 Fiscal Year Final Research Report
The analysis and application for periodontal treatment of FcRn which is tha passive IgG transporter in epithelial cells
| Project/Area Number |
22792085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OUHARA Kazuhisa 広島大学, 医歯薬保健学研究院, 助教 (80550425)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 歯肉上皮細胞 / FcRn / 歯周炎 / Ig |
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| Research Abstract |
The neonatal Fc receptor (FcRn) for IgG expressed in intestinalepithelium has been shown to be responsible for IgG transport. In this study, we determined the expression of FcRn in gingival epithelium and the function of FcRn. Our results suggested that FcRn expressed in GEC may contribute to the recycling of IgG in the oral cavity.
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Research Products
(5 results)
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[Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice2013
Author(s)
Furusho H, Miyauchi M, Hyogo H, Inubushi T, Ao M, OuharaK, Hisatune J, Kurihara H, Sugai M, Hayes CN, Nakahara T, Aikata H, Takahashi S, Chayama K, Takata T
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Journal Title
J Gastroenterol
Pages: Epub ahead of print
Peer Reviewed
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[Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans2013
Author(s)
Miyagawa T, Fujita T, Ouhara K,Matsuda S, Kajiya M, Hayashida K, Imai H, Yoshimoto T, Iwata T, Shiba H, Abiko Y, Kurihara H.
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Journal Title
Int Immunopharmacol
Volume: 15(2)
Pages: 340-7
DOI
Peer Reviewed
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