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2011 Fiscal Year Final Research Report

Preventive effects of hydrogen-rich water on periodontitis

Research Project

  • PDF
Project/Area Number 22792120
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionOkayama University

Principal Investigator

TOMOFUJI Takaaki  岡山大学, 岡山大学病院, 講師 (80335629)

Project Period (FY) 2010 – 2011
Keywords歯学 / 栄養 / トランスレーショナルリサーチ
Research Abstract

Reactive oxygen species(ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat periodontitis model. A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water. The rats with periodontitis which were treated with pure water showed a time-dependent increase in serum reactive oxygen metabolites(ROM) level. Compared to the rats without periodontitis, the periodontitis-induced rats which were given pure water also showed polymorphonuclear leukocyte infiltration and alveolar bone loss at 4 weeks. Hydrogen-rich water intake inhibited an increase in serum ROM level at 4 weeks. Such conditions prevented polymorphonuclear leukocyte infiltration and osteoclast differentiation following periodontitis progression. Furthermore, inflammatory signaling pathways, such as mitogen-activated protein kinases, were less activated in periodontal lesions from hydrogen-rich water-treated rats as compared with pure water-treated rats. Consuming hydrogen-rich water might be beneficial in suppressing periodontitis progression by decreasing ROS.

  • Research Products

    (24 results)

All 2012 2011 Other

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Effects of topical application of inorganic polyphosphate on tissue remodeling in rat inflamed gingiva2012

    • Author(s)
      Kasuyama K, Tomofuji T, Ekuni D, Azuma T, Irie K, Endo Y, Morita M
    • Journal Title

      J Periodont Res

      Volume: 47 Pages: 159-164

    • Peer Reviewed
  • [Journal Article] Combined effects of hydrogen sulphide and lipopolysaccharide on osteoclast differentiation in rats2012

    • Author(s)
      Irie K, Ekuni D, Tomofuji T, Endo Y, Kasuyama K, Yaegaki K, Morita M
    • Journal Title

      J Periodontol

      Volume: 83 Pages: 522-527

    • Peer Reviewed
  • [Journal Article] Supplementation of broccoli or Bifidobacterium longum-fermented broccoli suppresses serum lipid peroxidation and osteoclast differentiation on alveolar bone surface in rats fed a high-cholesterol diet2012

    • Author(s)
      Tomofuji T, Ekuni D, Azuma T, Irie K, Endo Y, Yamamoto T, Ishikado A, Sato T, Harada K, Suido H, Morita M
    • Journal Title

      Nutr Res

      Volume: 32 Pages: 301-307

    • Peer Reviewed
  • [Journal Article] Supplementation of green tea catechins in dentifrices improves gingival oxidative stress and periodontal inflammation2011

    • Author(s)
      Maruyama T, Tomofuji T, Endo Y, Irie K, Ekuni D, Azuma T, Tamaki N, Yamamoto T, Morita M
    • Journal Title

      Arch Oral Biol

      Volume: 56 Pages: 48-53

    • Peer Reviewed
  • [Journal Article] Occlusal disharmony induces BDNF level in rat submandibular gland2011

    • Author(s)
      Irie K, Ekuni D, Tomofuji T, Azuma T, Endo Y, Kasuyama K, Morita M
    • Journal Title

      Arch Oral Biol

      Volume: 56 Pages: 35-40

    • Peer Reviewed
  • [Journal Article] Sex difference in gingivitis relates to interaction of oral health behaviors in young people2011

    • Author(s)
      Furuta M, Ekuni D, Irie K, Azuma T, Tomofuji T, Ogura T, Morita M
    • Journal Title

      J Periodontol

      Volume: 82 Pages: 558-565

    • Peer Reviewed
  • [Journal Article] Effects of exercise training on gingival oxidative stress in obese rats2011

    • Author(s)
      Azuma T, Tomofuji T, Endo Y, Tamaki N, Ekuni D, Irie K, Kasuyama K, Kato T, Morita M
    • Journal Title

      Arch Oral Biol

      Volume: 56 Pages: 768-774

    • Peer Reviewed
  • [Journal Article] Relationships between malocculusion and heart rate variability indices in healthy young adults : A pilot study2011

    • Author(s)
      Ekuni D, Takeuchi N, Furuta M, Tomofuji T, Morita M
    • Journal Title

      Method Inform Med

      Volume: 50 Pages: 358-363

    • Peer Reviewed
  • [Journal Article] Occlusal disharmony increases amyloid-βin the rat hippocampus2011

    • Author(s)
      Ekuni D, Tomofuji T, Irie K, Azuma T, Endo Y, Kasuyama K, Morita M
    • Journal Title

      Neuromol Med

      Volume: 13 Pages: 197-203

    • Peer Reviewed
  • [Journal Article] Stage of hepatocellular carcinoma is associated with periodontitis2011

    • Author(s)
      Tamaki N, Takaki A, Tomofuji T, Endo Y, Kasuyama K, Ekuni D, Yasunaka T, Yamamoto K, Morita M
    • Journal Title

      J Clin Periodontol

      Volume: 38 Pages: 1015-1020

    • Peer Reviewed
  • [Journal Article] Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs inrats2011

    • Author(s)
      Tomofuji T, Ekuni D, Irie K, Azuma T, Tamaki N, Maruyama T, Yamamoto T, Watanabe T, Morita M
    • Journal Title

      Biomed Res

      Volume: 32 Pages: 343-349

    • Peer Reviewed
  • [Journal Article] Non-surgical periodontal treatment decreases plasma level of oxidized low-density lipoprotein and oxidative stress2011

    • Author(s)
      Tamaki N, Tomofuji T, Ekuni D, Yamanaka R, Morita M
    • Journal Title

      Clin Oral Invest

      Volume: 15 Pages: 953-958

    • Peer Reviewed
  • [Journal Article] Hydrogen-rich water attenuates experimental periodontitis in a rat model2011

    • Author(s)
      Kasuyama K, Tomofuji T, Ekuni D, Tamaki N, Azuma T, Endo Y, Morita M
    • Journal Title

      J Clin Periodontol

      Volume: 38 Pages: 1085-1090

    • Peer Reviewed
  • [Journal Article] Relationships between eating habits and periodontal condition in university students2011

    • Author(s)
      Tomofuji T, Furuta M, Ekuni D, Irie K, Azuma T, Ogura T, Morita M
    • Journal Title

      J Periodontol

      Volume: 82 Pages: 1642-1649

    • Peer Reviewed
  • [Journal Article] Gum chewing modulates heart rate variability under noise stress

    • Author(s)
      Ekuni D, Tom ofuji T, Takeuchi N, Morita M
    • Journal Title

      Acta Odontol Scand

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Effects of eating behaviors on being overweight in Japanese university students : A cross-sectional survey at the Okayama University

    • Author(s)
      Ekuni D, Furuta M, Tomofuji T, Irie K, Azuma T, Iwasaki Y, Morita M
    • Journal Title

      Asia Pac J Public Health

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Relationship between serum albumin concentration and periodontal condition in head and neck cancer patients

    • Author(s)
      Maruyama T, Yamanaka R, Yokoi A, Ekuni D, Tomofuji T, Mizukawa N, Onoda T, Eguchi M, Morita M
    • Journal Title

      J Periodontol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Objective and subjective assessment of eating quickly in youngpeople

    • Author(s)
      Ekuni D, Furuta M, Takeuchi N, Tomofuji T, Morita M
    • Journal Title

      Arch Oral Biol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model

    • Author(s)
      Ekuni D, Tomofuji T, Endo Y, Kasuyama K, Irie K, Azuma T, Tamaki N, Mizutani S, Kojima A, Morita M
    • Journal Title

      Arch Oral Biol

      Volume: (in press)

    • Peer Reviewed
  • [Presentation] 実験的歯周炎に対する水素水摂取の予防効果の検証2012

    • Author(s)
      友藤孝明, 粕山健太, 江國大輔, 入江浩一郎, 遠藤康正, 東哲司, 玉木直文, 森田学
    • Organizer
      第2回分子状水素医学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-02-11
  • [Presentation] 歯周病と全身の酸化ストレスとの関連性2011

    • Author(s)
      友藤孝明
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      北海道
    • Year and Date
      20110702-03
  • [Presentation] 抗酸化物を用いた歯周組織の健康の保持・増進を目指して-LIONAWARD受賞講演2011

    • Author(s)
      友藤孝明
    • Organizer
      第60回日本口腔衛生学会・総会
    • Place of Presentation
      千葉
    • Year and Date
      2011-10-09
  • [Presentation] 生涯自分の歯で食べ続けるために2011

    • Author(s)
      友藤孝明
    • Organizer
      平成23年度井笠愛育委員連合会・栄養改善協議会合同研修会
    • Place of Presentation
      岡山
    • Year and Date
      2011-10-06
  • [Remarks]

    • URL

      http://seika.nii.ac.jp

URL: 

Published: 2013-07-31  

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