2011 Fiscal Year Final Research Report
Preventive effects of hydrogen-rich water on periodontitis
| Project/Area Number |
22792120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 歯学 / 栄養 / トランスレーショナルリサーチ |
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| Research Abstract |
Reactive oxygen species(ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat periodontitis model. A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water. The rats with periodontitis which were treated with pure water showed a time-dependent increase in serum reactive oxygen metabolites(ROM) level. Compared to the rats without periodontitis, the periodontitis-induced rats which were given pure water also showed polymorphonuclear leukocyte infiltration and alveolar bone loss at 4 weeks. Hydrogen-rich water intake inhibited an increase in serum ROM level at 4 weeks. Such conditions prevented polymorphonuclear leukocyte infiltration and osteoclast differentiation following periodontitis progression. Furthermore, inflammatory signaling pathways, such as mitogen-activated protein kinases, were less activated in periodontal lesions from hydrogen-rich water-treated rats as compared with pure water-treated rats. Consuming hydrogen-rich water might be beneficial in suppressing periodontitis progression by decreasing ROS.
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[Journal Article] Supplementation of broccoli or Bifidobacterium longum-fermented broccoli suppresses serum lipid peroxidation and osteoclast differentiation on alveolar bone surface in rats fed a high-cholesterol diet2012
Author(s)
Tomofuji T, Ekuni D, Azuma T, Irie K, Endo Y, Yamamoto T, Ishikado A, Sato T, Harada K, Suido H, Morita M
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Journal Title
Nutr Res
Volume: 32
Pages: 301-307
Peer Reviewed
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