2011 Fiscal Year Final Research Report
Study on host defensive system of oral mucosa to volatile sulfide compounds in oral cavity.
Project/Area Number |
22792123
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Social dentistry
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Research Institution | Kyushu Dental College |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Keywords | 揮発性硫化物 / 口腔粘膜上皮 / 生体防御機構 / チオールメチルトランスフェラーゼ / 無毒化 |
Research Abstract |
This study verified the existence of the two enzymes[Thiomethyltransferase(TMT) and Thiosulfate sulfurtransferase(RHOD)], which decomposed volatile sulfide compounds(VSC) generated from oral bacteria, in oral mucosa. However, we have not succeeded to obtain the specific primers for RT-PCR to detect the gene expression of TMT and RHOD in oral keratinocyte until now, therefore, this study has not demonstrated the existence of the enzyme decomposing VSC in oral mucosa.
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Research Products
(6 results)
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[Presentation] Neutral Endopeptidase and Endothelin-converting Enzyme in Human Buccal Mucosal Epithelium2010
Author(s)
Kinoshita, N., Awano, S., Yoshida, A., Soh, I., Mineoka, T., and Ansai, T
Organizer
58th Japanese Association for Dental Research
Place of Presentation
Kitakyushu
Year and Date
20101120-21