2011 Fiscal Year Final Research Report
Functional proteomic analysis to identify memory formation-related proteins in the Drosophila mushroom bodies.
| Project/Area Number |
22800012
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 記憶学習 / ショウジョウバエ / プロテオミクス / CREB |
|---|
| Research Abstract |
I started to develop the new methods to approach the molecular or cellular mechanisms underlying memory formation, storage, retrieval in this study. I tried to identify new factors related to learning and memory by proteomics analysis and then, I planed to determine the cells in which they would function. But I failed to establish the methods to concentrate the synapse-specific proteins. So I changed my approach into identify the cells recruited into memory traces. I generated CREB activity reporter flies and succeeded in labeling the cells in response to long-term memory formation.
|
