Development of novel DDS carriers incorporating water-soluble drug and potential for click release

2011 Fiscal Year Final Research Report

• Project/Area Number: 22800013
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The University of Tokyo
• Principal Investigator: MIURA Yutaka 東京大学, 医学部・附属病院, 特任助教 (40557980)
• Project Period (FY): 2010 – 2011
• Keywords: ドラッグデリバリー / ナノ材料

Research Abstract

Drug delivery system(DDS) have enormous potential to improve the efficacy of cancer treatment by chemical modification of drug vehicles. However, limited DDS strategies have been reported with water-soluble drugs, and so far no candidate to reach up to the clinical use. We have developed novel strategy to prepare DDS carrier incorporating water-soluble drug : gemcitabine, and study the potential of this carrier for DDS usage. The contents were the followings.
i) Preparation of gemcitabine incorporated DDS carrier.
ii) Drug release behavior : pH-responsive
iii) in vitro activity of carrier.

Research Products

• [Journal Article] Impact of polyplex micellesinstalled with cyclic RGD peptide as ligandon gene delivery to vascular lesions (2012)
  • Author(s): Kagaya, H., Oba, M., Miura, Y., Koyama, H., Ishii, T., Takato, T., Kataoka, K., Miyata, T
  • Journal Title: GeneTherapy Volume: 19 Pages: 61-69
  • Peer Reviewed
• [Journal Article] Graphene/Polyurethane Nanocompositesfor Improved Gas Barrier and Electrical Conductivity (2010)
  • Author(s): Kim, H., Miura, Y., Macosko, C., W
  • Journal Title: Chemistry of Materials Volume: 22 Pages: 3441-3450
  • Peer Reviewed
• [Journal Article] Precise synthesis of poly(1-adamantyl methacrylate) by atom transfer radical polymerization (2010)
  • Author(s): Fuchise, K., Sone, M., Miura, Y., Sakai, R., Narumi, A., Sato, S, . Satoh, T., Kakuchi, T
  • Journal Title: Polymer Journal Volume: 42 Pages: 626-631
  • Peer Reviewed
• [Presentation] Improved physicochemical properties of antitumor drugplatinum-loaded micelles withα-helix intheir core budgets (2011)
  • Author(s): 三浦裕
  • Organizer: The 11th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: Lahaina, Maui, Hawaii
  • Year and Date: 2011-12-16
• [Presentation] 白金錯体制がん剤内包高分子ミセルのコア中における高次構造と形態相関 (2011)
  • Author(s): 三浦裕
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山大学津島キャンパス
  • Year and Date: 2011-09-28
• [Presentation] 白金錯体制がん剤を内包する高分子ミセル型DDSのコア構造に着目した機能制御 (2011)
  • Author(s): 三浦裕
  • Organizer: 第27回日本DDS学会
  • Place of Presentation: 東京大学本郷キャンパス
  • Year and Date: 2011-06-09
• [Presentation] Characteristics of antitumordrug DACHPt-loaded micelles formedfrom conformation-controlledPEG-b-P(Glu) (2011)
  • Author(s): 三浦裕
  • Organizer: 第60回高分子年次大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-05-25
• [Presentation] 白金錯体制がん剤DACHPtとPEG-P(Glu)ブロック共重合体から形成される高分子ミセルの構造解析 (2010)
  • Author(s): 三浦裕
  • Organizer: 第32回日本バイオマテリアル学会
  • Place of Presentation: グランドプリンスホテル広島
  • Year and Date: 2010-11-29
• [Presentation] 表層を機能化したプラチナ制がん剤内包ミセルの合成とその評価 (2010)
  • Author(s): 三浦裕
  • Organizer: 第59回高分子討論会
  • Place of Presentation: 北海道大学高等教育機能開発センター
  • Year and Date: 2010-09-16