Research of the mechanisms of progression and metastasis using mouse gastrointestinal cancer models

2011 Fiscal Year Final Research Report

• Project/Area Number: 22800025
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Carcinogenesis
• Research Institution: Kanazawa University
• Principal Investigator: ISHIKAWA Tomo-o 金沢大学, がん進展制御研究所, 助教 (70322162)
• Project Period (FY): 2010 – 2011
• Keywords: がん / マウスモデル / 炎症 / 転移

Research Abstract

To analyze the mechanisms of gastrointestinal cancer progression and metastasis which result in many patient death, tumor cells from mouse genetic models were used to establish a new in vitro system. Tumor cells were isolated from genetic and chemical mouse models for gastric and intestinal tumor formation, cultured and passaged. Transfection of expression vector was also possible in these cells. This system can be utilized for the identification of candidate genes which relate to cancer progression and metastasis.

Research Products

• [Journal Article] Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells (2012)
  • Author(s): Kong, D., Piao, Y.-S., Yamashita, S., Oshima, H., Oguma, K., Fushida, S., Fujimura, T., Minamoto, T., Seno, H., Yamada, Y., Satou, K., Ushijima, T., Ishikawa, T. and Oshima, M.
  • Journal Title: Oncogene
  • DOI: DOI:10.1038/onc.2011.558
  • Peer Reviewed
• [Journal Article] Cox-2 deletion in myeloid and endothelial cells, but not in epithelialcells (2011)
  • Author(s): Ishikawa, T., Oshima, M. and Herschman, H. R.
  • Journal Title: Carcinogenesis Volume: 32 Pages: 417-426
  • DOI: DOI:10.1093/carcin/bgq268
  • Peer Reviewed
• [Journal Article] Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis (2011)
  • Author(s): Oshima, H., Popivanova, B. K., Oguma, K., Kong, D., Ishikawa, T. and Oshima, M.
  • Journal Title: Cancer Sci. Volume: 102 Pages: 713-719
  • DOI: DOI:10.1111/j.1349-7006.2011.01847.x
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 signaling and bacterial infection recruit tumor-promoting macrophages to mouse gastric tumors (2011)
  • Author(s): Oshima, H., Hioki, K., Popivannova, B. K., Oguma, K., Van Rooijen, N., Ishikawa, T. and Oshima, M.
  • Journal Title: Gastroenterology Volume: 140 Pages: 596-607
  • DOI: DOI:10.1053/j.gastro.2010.11.007
  • Peer Reviewed
• [Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis (2011)
  • Author(s): Ishikawa, T. and Oshima, M
  • Organizer: 16th Japan-Korea Cancer Research Workshop
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2011-12-09
• [Presentation] Effects of inflammation on the epithelial differentiation and tumorigenesis (2011)
  • Author(s): Ishikawa, T. and Oshima, M.
  • Organizer: 70th Annual Meeting for Japanese cancer
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] Tumorformation without Cyclooxygenase-2(Cox-2) expression in mouse model ofcolitis-associated cancer (2010)
  • Author(s): Ishikawa, T. and Oshima, M
  • Organizer: 69Th Annua lMeeting for Japanese Cancer Association
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Remarks]
  • URL: http://genetics.w3.kanazawa-u.ac.jp