2011 Fiscal Year Final Research Report
The role of reactive oxygen and nitrogen species in rheumatoid arthritis-induced skeletal muscle dysfunction.
Project/Area Number |
22800051
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Sapporo Medical University |
Principal Investigator |
YAMADA Takashi 札幌医科大学, 保健医療学部, 講師 (50583176)
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Project Period (FY) |
2010 – 2011
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Keywords | 関節リウマチ / 骨格筋 / 収縮機能 / 活性酸素・窒素種 / ペルオキシナイトライト / 細胞内Ca^<2+>濃度 / リアノジン受容体 / 酸化的修飾 |
Research Abstract |
Peroxynitrite anion(ONOO^-) has been proposed to be one of the principal causes of the muscle wasting and weakness observed in rheumatoid arthritis. However, the biological effects of ONOO^-on skeletal muscle remains poorly understood. The present study investigated the effects of ONOO^-donor 3-morpholinosynonimine(SIN-1) on the contractile properties of intact fibres from a mouse foot muscle. Our results suggest that ONOO^-induces the skeletal muscle dysfunction due to an irreversible oxidation of sarcoplasmic reticulum Ca^<2+> release channels.
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[Journal Article] Mitochondrial production of reactive oxygen species contributes to the{beta}-adrenergic stimulation of mouse cardiomycytes2011
Author(s)
Andersson, DC., Fauconnier, J., Yamada, T., Lacampagne, A., Zhang, SJ., Katz, A. and Westerblad, H.
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Journal Title
J. Physiol
Volume: 589
Pages: 1791-1801
Peer Reviewed
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[Journal Article] Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice2010
Author(s)
Bruton, JD., Aydin, J., Yamada, T., Shabalina, IG., Ivarsson, N., Zhang, SJ., Wada, M., Tavi, P., Nedergaard, J., Katz, A. and Westerblad, H.
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Journal Title
J. Physiol
Volume: 588
Pages: 4275-4288
Peer Reviewed
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[Presentation] Effects of peroxynitrite on intact, single skeletal muscle fibres from the mouse2011
Author(s)
Yamada, T., Ivarsson, N., Kanzaki, K., Kuratani, M., Matsunaga, S., Wada, M., Westerblad, H. and Bruton, JD.
Organizer
40^<th> European Muscle Conference
Place of Presentation
Berlin
Year and Date
20110900
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