2011 Fiscal Year Final Research Report
Development of the cytoplasmic molecular delivery by the photodynamic treatment inducing the mild oxidation of the plasma membrane
| Project/Area Number |
22800059
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Saitama Medical University |
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Principal Investigator |
MIYAMOTO Yuichi 埼玉医科大学, 保健医療学部, 准教授 (00313718)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生物・生体工学 / ナノバイオ / 細胞・組織 / 光線力学的治療 |
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| Research Abstract |
Photodynamic therapy(PDT) established as a curative treatment for the cancer has acquired anticancer efficacy by producing reactive oxygen species on theplasma membrane orthe cytoplasmic organelle. In this study, I employed PDT inducing no remarkable cell injury and investigate whether the PDT(1) can deliverthe macromoleculeto the cell,(2) can enhance the cytotoxic effect of the anticancer drug. As the results, the PDT would transfer a molecule of 10 kDa or less through the plasma membrane of the HeLa cells and enhance the cytotoxic effects of Bleomycin.
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