2011 Fiscal Year Final Research Report
Analysis of anti-aging mechanism of exercise via histone modifications
| Project/Area Number |
22800062
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Juntendo University |
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Principal Investigator |
KAWAKAMI Kyojiro 順天堂大学, スポーツ健康科学部, 研究員 (90589227)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ヒストン修飾 / エピジェネティクス / 老化 / 運動 / アセチル化 |
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| Research Abstract |
We analyzed anti-aging mechanism of exercise focused on histone modifications. We found dimethylation of histone H3 lysine 4 was decreased in rat gastrocnemius muscle. However, exercise didn’t affect histone modifications. In rat kidney, histone H3 lysine 9 acetylation and serine 10 phosphorylation was increased with age. Moreover, inflammatory genes mRNA were increased with age, and histone H3 lysine 9 acetylation was presented in the vicinity of the gene transcription start site.
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