2011 Fiscal Year Final Research Report
Analysis of anti-aging mechanism of exercise via histone modifications
| Project/Area Number |
22800062
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
KAWAKAMI Kyojiro 順天堂大学, スポーツ健康科学部, 研究員 (90589227)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | ヒストン修飾 / エピジェネティクス / 老化 / 運動 / アセチル化 |
|---|
| Research Abstract |
We analyzed anti-aging mechanism of exercise focused on histone modifications. We found dimethylation of histone H3 lysine 4 was decreased in rat gastrocnemius muscle. However, exercise didn’t affect histone modifications. In rat kidney, histone H3 lysine 9 acetylation and serine 10 phosphorylation was increased with age. Moreover, inflammatory genes mRNA were increased with age, and histone H3 lysine 9 acetylation was presented in the vicinity of the gene transcription start site.
|
Research Products
(10 results)
