2011 Fiscal Year Final Research Report
Electrophysiological and neuroanatomical analyses of peripheral nerve transection-induced multiple-innervation of lemniscal fibers in the somatosensory thalamus of mice
| Project/Area Number |
22800063
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経損傷 / 視床 / シナプス |
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| Research Abstract |
Relay neurons in the somatosensory thalamus of mice receive unusual multiple lemniscal fiber innervations after peripheral nerve transection ; however the origin and wiring of the new lemniscal fibers were unknown. In this study, I found electrophysiological and anatomical evidence for ectopic collaterals of lemniscal fibers innervating neighbor relay neurons after the injury. The rewiring found in this study may be a neural basis for changes in receptive fields in the thalamus or phantom sensations after deafferentations.
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