2010 Fiscal Year Final Research Report
Construction of stabilized PNA/DNA invasion complex for the analysis of higher-order structure of DNA
| Project/Area Number |
22850004
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
AIBA Yuichiro The University of Tokyo, 先端科学技術研究センター, 特任助教 (10581085)
|
|---|
| Project Period (FY) |
2010
|
| Keywords | 核酸 / バイオテクノロジー / 遺伝子 / ゲノム / PNA |
|---|
| Research Abstract |
Peptide Nucleic Acid (PNA) is a one of DNA analogues and it can form stable duplex with its complementary DNA. Furthermore, PNA can "invade" a double-stranded DNA sequence-selectively (formation of invasion complex) and this special recognition mode of double-stranded DNA is called "strand invasion". In this study, we developed a strategy to stabilize the invasion complex for the analysis of higher-order structure of DNA.
|
